Southwest Airlines
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United States
Orlando International Airport
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United States
McGhee Tyson Airport
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Scan through all non-stop flights from Orlando to Knoxville. The full flight schedule below gives an overview of all non-stop flights from MCO to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
In total there are 2 airlines operating nonstop flights from Orlando MCO to Knoxville TYS. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their MCO TYS flight schedule.
Flights from MCO to TYS are operated 9 times a week, with an average of 1 flight per day. Departure times vary between 08:41 - 21:53. The earliest flight departs at 08:41, the last flight departs at 21:53. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Orlando to Knoxville takes 1 hour and 48 minutes. The flight distance between Orlando and Knoxville is 533 miles (or 858 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There are 9 flights per week flying from Orlando to Knoxville (as of April 2026).
1 hour and 48 minutes is the average flight time from Orlando to Knoxville.
The distance from Orlando to Knoxville is 533 miles (858 kilometers).
Allegiant and Southwest Airlines are flying nonstop from Orlando to Knoxville.
There are no alliances flying direct from Orlando to Knoxville at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Orlando to Knoxville:
The earliest flight departs at 08:41 from Orlando and arrives at 10:24 at Knoxville.
The latest flight departs at 21:53 from Orlando and arrives at 23:39 at Knoxville.
533 miles (858 km) · 1h 48m
12:05
13:55
Southwest Airlines
WN 3912
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
15:10
16:55
Southwest Airlines
WN 2718
Southwest Airlines
Boeing 757
Y
W
J
F
15:25
17:10
Southwest Airlines
WN 2718
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
15:41
17:30
Allegiant
G4 3040
Allegiant
Airbus A320-100/200
Y
W
J
F
15:41
17:30
Allegiant
G4 3044
Allegiant
Airbus A320-100/200
Y
W
J
F
16:25
18:10
Southwest Airlines
WN 2718
Southwest Airlines
Boeing 757
Y
W
J
F
16:32
18:21
Allegiant
G4 3061
Allegiant
Airbus A320-100/200
Y
W
J
F
16:32
18:21
Allegiant
G4 1418
Allegiant
Airbus A320-100/200
Y
W
J
F
16:40
18:35
Southwest Airlines
WN 3912
Southwest Airlines
Boeing 757
Y
W
J
F
16:50
18:45
Southwest Airlines
WN 3912
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
17:10
19:00
Southwest Airlines
WN 2718
Southwest Airlines
Boeing 757
Y
W
J
F
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