Southwest Airlines
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United States
Lambert-Saint Louis International Airport
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United States
Northwest Florida Beaches International Airport
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Scan through all non-stop flights from St. Louis to Panama City. The full flight schedule below gives an overview of all non-stop flights from STL to ECP, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Panama City is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Panama City any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from St. Louis STL to Panama City ECP, which is Southwest Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their STL ECP flight schedule.
Flights from STL to ECP are operated 9 times a week, with an average of 1 flight per day. Departure times vary between 08:25 - 20:35. The earliest flight departs at 08:25, the last flight departs at 20:35. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from St. Louis to Panama City takes 1 hour and 45 minutes. The flight distance between St. Louis and Panama City is 634 miles (or 1,020 km).
There is 1 airport in Panama City: Northwest Florida Beaches International Airport (ECP).
There are 9 flights per week flying from St. Louis to Panama City (as of April 2026).
1 hour and 45 minutes is the average flight time from St. Louis to Panama City.
The distance from St. Louis to Panama City is 634 miles (1,020 kilometers).
Southwest Airlines is the only airline flying nonstop from St. Louis to Panama City.
There are no alliances flying direct from St. Louis to Panama City at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from St. Louis to Panama City:
The earliest flight departs at 08:25 from St. Louis and arrives at 10:10 at Panama City.
The latest flight departs at 20:35 from St. Louis and arrives at 22:20 at Panama City.
634 miles (1,020 km) · 1h 45m
08:45
10:30
Southwest Airlines
WN 161
Southwest Airlines
Boeing 757
Y
W
J
F
10:30
12:15
Southwest Airlines
WN 161
Southwest Airlines
Boeing 757
Y
W
J
F
10:40
12:30
Southwest Airlines
WN 2288
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
11:25
13:15
Southwest Airlines
WN 2810
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
12:25
14:15
Southwest Airlines
WN 1790
Southwest Airlines
Boeing 757
Y
W
J
F
12:45
14:30
Southwest Airlines
WN 2810
Southwest Airlines
Boeing 757
Y
W
J
F
14:30
16:20
Southwest Airlines
WN 2810
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
16:35
18:20
Southwest Airlines
WN 161
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
17:15
19:00
Southwest Airlines
WN 428
Southwest Airlines
Boeing 757
Y
W
J
F
17:25
19:10
Southwest Airlines
WN 290
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
18:40
20:25
Southwest Airlines
WN 161
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
19:55
21:40
Southwest Airlines
WN 428
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
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