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Denver International Airport
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United States
McGhee Tyson Airport
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Scan through all non-stop flights from Denver to Knoxville. The full flight schedule below gives an overview of all non-stop flights from DEN to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
In total there are 4 airlines operating nonstop flights from Denver DEN to Knoxville TYS. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their DEN TYS flight schedule.
Flights from DEN to TYS are operated 18 times a week, with an average of 3 flights per day. Departure times vary between 08:26 - 17:45. The earliest flight departs at 08:26, the last flight departs at 17:45. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Denver to Knoxville takes 2 hours and 49 minutes. The flight distance between Denver and Knoxville is 1,159 miles (or 1,865 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There are 18 flights per week flying from Denver to Knoxville (as of April 2026).
2 hours and 49 minutes is the average flight time from Denver to Knoxville.
The distance from Denver to Knoxville is 1,159 miles (1,865 kilometers).
Allegiant, Frontier Airlines, Southwest Airlines and United Airlines are flying nonstop from Denver to Knoxville.
Star Alliance is currently the only alliance flying nonstop from Denver to Knoxville.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Denver to Knoxville:
The earliest flight departs at 08:26 from Denver and arrives at 13:11 at Knoxville.
The latest flight departs at 17:45 from Denver and arrives at 22:38 at Knoxville.
1,159 miles (1,865 km) · 2h 49m
10:10
15:06
United Airlines
Star Alliance
UA 2041
United Airlines
Boeing 737-800
Y
W
J
F
10:20
15:17
United Airlines
Star Alliance
UA 2041
United Airlines
Airbus A319
Y
W
J
F
10:30
15:15
Southwest Airlines
WN 3906
Southwest Airlines
Boeing 757
Y
W
J
F
10:40
15:28
Frontier Airlines
F9 2374
Frontier Airlines
Airbus A320neo
Y
W
J
F
10:45
15:33
Frontier Airlines
F9 2374
Frontier Airlines
Airbus A321-100/200
Y
W
J
F
10:45
15:33
Frontier Airlines
F9 2374
Frontier Airlines
Airbus A321neo
Y
W
J
F
14:45
19:35
Southwest Airlines
WN 3906
Southwest Airlines
Boeing 757
Y
W
J
F
17:25
22:29
United Airlines
Star Alliance
UA 4774
United Airlines
Embraer 175
Y
W
J
F
17:27
22:23
United Airlines
Star Alliance
UA 2473
United Airlines
Airbus A319
Y
W
J
F
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