Delta
SkyTeam
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United States
Detroit Metropolitan Wayne County Airport
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United States
McGhee Tyson Airport
Click to show full flight schedule
Scan through all non-stop flights from Detroit to Knoxville. The full flight schedule below gives an overview of all non-stop flights from DTW to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Detroit DTW to Knoxville TYS, which is Delta. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their DTW TYS flight schedule.
Flights from DTW to TYS are operated 20 times a week, with an average of 3 flights per day. Departure times vary between 08:25 - 19:55. The earliest flight departs at 08:25, the last flight departs at 19:55. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Detroit to Knoxville takes 1 hour and 34 minutes. The flight distance between Detroit and Knoxville is 443 miles (or 713 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There are 20 flights per week flying from Detroit to Knoxville (as of April 2026).
1 hour and 34 minutes is the average flight time from Detroit to Knoxville.
The distance from Detroit to Knoxville is 443 miles (713 kilometers).
Delta is the only airline flying nonstop from Detroit to Knoxville.
SkyTeam is currently the only alliance flying nonstop from Detroit to Knoxville.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Detroit to Knoxville:
The earliest flight departs at 08:25 from Detroit and arrives at 10:04 at Knoxville.
The latest flight departs at 19:55 from Detroit and arrives at 21:28 at Knoxville.
443 miles (713 km) · 1h 34m
08:40
10:21
Delta
SkyTeam
DL 5347
Delta
Canadair Regional Jet 900
Y
W
J
F
08:50
10:31
Delta
SkyTeam
DL 5347
Delta
Canadair Regional Jet 900
Y
W
J
F
08:59
10:40
Delta
SkyTeam
DL 5347
Delta
Canadair Regional Jet 900
Y
W
J
F
15:03
16:42
Delta
SkyTeam
DL 4941
Delta
Canadair Regional Jet 900
Y
W
J
F
15:03
16:42
Delta
SkyTeam
DL 4941
Delta
Canadair Regional Jet 900
Y
W
J
F
15:10
16:43
Delta
SkyTeam
DL 5434
Delta
Canadair Regional Jet 900
Y
W
J
F
19:34
21:06
Delta
SkyTeam
DL 5138
Delta
Canadair Regional Jet 700
Y
W
J
F
19:34
21:06
Delta
SkyTeam
DL 5138
Delta
Canadair Regional Jet 700
Y
W
J
F
19:45
21:20
Delta
SkyTeam
DL 5138
Delta
Canadair Regional Jet 700
Y
W
J
F
19:45
21:20
Delta
SkyTeam
DL 5138
Delta
Canadair Regional Jet 700
Y
W
J
F
19:45
21:20
Delta
SkyTeam
DL 5138
Delta
Canadair Regional Jet 700
Y
W
J
F
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