Southwest Airlines
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United States
Midway International Airport
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United States
Lambert-Saint Louis International Airport
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Scan through all non-stop flights from Chicago to St. Louis. The full flight schedule below gives an overview of all non-stop flights from MDW to STL, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
St. Louis is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit St. Louis any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Chicago MDW to St. Louis STL, which is Southwest Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their MDW STL flight schedule.
Flights from MDW to STL are operated 34 times a week, with an average of 5 flights per day. Departure times vary between 06:25 - 22:15. The earliest flight departs at 06:25, the last flight departs at 22:15. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Chicago to St. Louis takes 1 hour and 10 minutes. The flight distance between Chicago and St. Louis is 251 miles (or 404 km).
There is 1 airport in St. Louis: Lambert-Saint Louis International Airport (STL).
There are 34 flights per week flying from Chicago to St. Louis (as of April 2026).
1 hour and 10 minutes is the average flight time from Chicago to St. Louis.
The distance from Chicago to St. Louis is 251 miles (404 kilometers).
Southwest Airlines is the only airline flying nonstop from Chicago to St. Louis.
There are no alliances flying direct from Chicago to St. Louis at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Chicago to St. Louis:
The earliest flight departs at 06:25 from Chicago and arrives at 07:45 at St. Louis.
The latest flight departs at 22:15 from Chicago and arrives at 23:30 at St. Louis.
251 miles (404 km) · 1h 10m
06:25
07:45
Southwest Airlines
WN 2458
Southwest Airlines
Boeing 757
Y
W
J
F
07:45
09:00
Southwest Airlines
WN 2458
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
07:50
09:05
Southwest Airlines
WN 2630
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
08:10
09:30
Southwest Airlines
WN 3978
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
08:10
09:25
Southwest Airlines
WN 2630
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
08:15
09:30
Southwest Airlines
WN 2630
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
08:15
09:30
Southwest Airlines
WN 2630
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
09:00
10:15
Southwest Airlines
WN 1862
Southwest Airlines
Boeing 757
Y
W
J
F
09:15
10:30
Southwest Airlines
WN 1862
Southwest Airlines
Boeing 757
Y
W
J
F
10:15
11:30
Southwest Airlines
WN 265
Southwest Airlines
Boeing 757
Y
W
J
F
10:15
11:30
Southwest Airlines
WN 1164
Southwest Airlines
Boeing 757
Y
W
J
F
10:50
12:05
Southwest Airlines
WN 1164
Southwest Airlines
Boeing 757
Y
W
J
F
11:15
12:30
Southwest Airlines
WN 3751
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
11:40
12:55
Southwest Airlines
WN 1422
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
12:30
13:40
Southwest Airlines
WN 3751
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
12:45
14:00
Southwest Airlines
WN 2022
Southwest Airlines
Boeing 757
Y
W
J
F
13:55
15:05
Southwest Airlines
WN 1370
Southwest Airlines
Boeing 757
Y
W
J
F
14:10
15:25
Southwest Airlines
WN 3144
Southwest Airlines
Boeing 757
Y
W
J
F
14:35
15:50
Southwest Airlines
WN 577
Southwest Airlines
Boeing 757
Y
W
J
F
16:05
17:20
Southwest Airlines
WN 2897
Southwest Airlines
Boeing 757
Y
W
J
F
16:40
17:55
Southwest Airlines
WN 3395
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
17:40
18:55
Southwest Airlines
WN 2253
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
17:40
18:55
Southwest Airlines
WN 2253
Southwest Airlines
Boeing 757
Y
W
J
F
17:40
18:55
Southwest Airlines
WN 3395
Southwest Airlines
Boeing 757
Y
W
J
F
17:50
19:05
Southwest Airlines
WN 2458
Southwest Airlines
Boeing 757
Y
W
J
F
17:50
19:05
Southwest Airlines
WN 2253
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
18:30
19:45
Southwest Airlines
WN 3395
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
18:30
19:45
Southwest Airlines
WN 116
Southwest Airlines
Boeing 757
Y
W
J
F
20:55
22:10
Southwest Airlines
WN 3396
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
21:30
22:45
Southwest Airlines
WN 3396
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
21:40
22:55
Southwest Airlines
WN 397
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
21:45
23:00
Southwest Airlines
WN 3396
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
22:05
23:20
Southwest Airlines
WN 2253
Southwest Airlines
Boeing 757
Y
W
J
F
22:15
23:30
Southwest Airlines
WN 4009
Southwest Airlines
Boeing 757
Y
W
J
F
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