Southwest Airlines
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United States
Lambert-Saint Louis International Airport
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United States
Midway International Airport
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Scan through all non-stop flights from St. Louis to Chicago. The full flight schedule below gives an overview of all non-stop flights from STL to MDW, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Known for its continental climate, Chicago features hot, humid summers with temperatures above 30°C (86°F) and cold, snowy winters that often drop below 0°C (32°F). This striking seasonal contrast offers travelers a variety of activities, from summer hiking to winter sports, ensuring year-round appeal.
The best time to visit Chicago is from March to November, covering spring, summer, and fall. While summer can be hot, it also sees slightly more rainfall than other seasons.
Currently, there is only one airline operating non-stop flights from St. Louis STL to Chicago MDW, which is Southwest Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their STL MDW flight schedule.
Flights from STL to MDW are operated 34 times a week, with an average of 5 flights per day. Departure times vary between 05:10 - 22:00. The earliest flight departs at 05:10, the last flight departs at 22:00. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from St. Louis to Chicago takes 1 hour and 5 minutes. The flight distance between St. Louis and Chicago is 251 miles (or 404 km).
There are 2 airports in Chicago: Midway International Airport (MDW) and O'Hare International Airport (ORD).
There are 34 flights per week flying from St. Louis to Chicago (as of April 2026).
1 hour and 5 minutes is the average flight time from St. Louis to Chicago.
The distance from St. Louis to Chicago is 251 miles (404 kilometers).
Southwest Airlines is the only airline flying nonstop from St. Louis to Chicago.
There are no alliances flying direct from St. Louis to Chicago at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from St. Louis to Chicago:
The earliest flight departs at 05:10 from St. Louis and arrives at 06:20 at Chicago.
The latest flight departs at 22:00 from St. Louis and arrives at 23:05 at Chicago.
251 miles (404 km) · 1h 5m
05:10
06:20
Southwest Airlines
WN 649
Southwest Airlines
Boeing 737 MAX 8
Y
W
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F
05:20
06:30
Southwest Airlines
WN 1181
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
05:25
06:35
Southwest Airlines
WN 4489
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
05:30
06:40
Southwest Airlines
WN 649
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
05:35
06:45
Southwest Airlines
WN 4489
Southwest Airlines
Boeing 757
Y
W
J
F
05:40
06:50
Southwest Airlines
WN 4489
Southwest Airlines
Boeing 757
Y
W
J
F
05:40
06:50
Southwest Airlines
WN 4489
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
07:20
08:30
Southwest Airlines
WN 397
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
10:25
11:35
Southwest Airlines
WN 3964
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
10:35
11:45
Southwest Airlines
WN 770
Southwest Airlines
Boeing 757
Y
W
J
F
10:50
12:00
Southwest Airlines
WN 770
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
10:50
12:00
Southwest Airlines
WN 3613
Southwest Airlines
Boeing 757
Y
W
J
F
11:00
12:10
Southwest Airlines
WN 770
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
11:00
12:10
Southwest Airlines
WN 3613
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
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F
13:45
14:55
Southwest Airlines
WN 826
Southwest Airlines
Boeing 757
Y
W
J
F
13:45
14:55
Southwest Airlines
WN 826
Southwest Airlines
Boeing 757
Y
W
J
F
14:05
15:15
Southwest Airlines
WN 826
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
14:10
15:20
Southwest Airlines
WN 826
Southwest Airlines
Boeing 757
Y
W
J
F
14:15
15:20
Southwest Airlines
WN 2256
Southwest Airlines
Boeing 757
Y
W
J
F
15:55
17:05
Southwest Airlines
WN 1764
Southwest Airlines
Boeing 757
Y
W
J
F
16:40
17:45
Southwest Airlines
WN 373
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
16:40
17:50
Southwest Airlines
WN 1764
Southwest Airlines
Boeing 757
Y
W
J
F
16:40
17:50
Southwest Airlines
WN 1764
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
16:45
17:50
Southwest Airlines
WN 373
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
16:45
17:50
Southwest Airlines
WN 373
Southwest Airlines
Boeing 757
Y
W
J
F
16:45
17:50
Southwest Airlines
WN 373
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
18:55
20:05
Southwest Airlines
WN 1764
Southwest Airlines
Boeing 757
Y
W
J
F
20:45
21:50
Southwest Airlines
WN 3166
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
20:45
21:50
Southwest Airlines
WN 3166
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
21:35
22:40
Southwest Airlines
WN 4549
Southwest Airlines
Boeing 757
Y
W
J
F
21:40
22:45
Southwest Airlines
WN 3411
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
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F
21:40
22:45
Southwest Airlines
WN 3411
Southwest Airlines
Boeing 757
Y
W
J
F
21:40
22:45
Southwest Airlines
WN 3411
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
21:40
22:45
Southwest Airlines
WN 3411
Southwest Airlines
Boeing 757
Y
W
J
F
21:50
23:00
Southwest Airlines
WN 4549
Southwest Airlines
Boeing 757
Y
W
J
F
22:00
23:05
Southwest Airlines
WN 3166
Southwest Airlines
Boeing 757
Y
W
J
F
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