Delta
SkyTeam
Did you mean flights from Knoxville to Minneapolis?
United States
Minneapolis-Saint Paul International Airport
Switch direction
United States
McGhee Tyson Airport
Click to show full flight schedule
Scan through all non-stop flights from Minneapolis to Knoxville. The full flight schedule below gives an overview of all non-stop flights from MSP to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Minneapolis MSP to Knoxville TYS, which is Delta. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their MSP TYS flight schedule.
Flights from MSP to TYS are operated 7 times a week, with an average of 1 flight per day. Departure times vary between 13:23 - 19:50. The earliest flight departs at 13:23, the last flight departs at 19:50. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Minneapolis to Knoxville takes 2 hours and 11 minutes. The flight distance between Minneapolis and Knoxville is 791 miles (or 1,273 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There are 7 flights per week flying from Minneapolis to Knoxville (as of April 2026).
2 hours and 11 minutes is the average flight time from Minneapolis to Knoxville.
The distance from Minneapolis to Knoxville is 791 miles (1,273 kilometers).
Delta is the only airline flying nonstop from Minneapolis to Knoxville.
SkyTeam is currently the only alliance flying nonstop from Minneapolis to Knoxville.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Minneapolis to Knoxville:
The earliest flight departs at 13:23 from Minneapolis and arrives at 16:34 at Knoxville.
The latest flight departs at 19:50 from Minneapolis and arrives at 23:03 at Knoxville.
791 miles (1,273 km) · 2h 11m
19:30
22:43
Delta
SkyTeam
DL 5527
Delta
Canadair Regional Jet 900
Y
W
J
F
19:45
22:59
Delta
SkyTeam
DL 5527
Delta
Canadair Regional Jet 900
Y
W
J
F
19:50
23:03
Delta
SkyTeam
DL 5527
Delta
Canadair Regional Jet 900
Y
W
J
F
Click to Check Prices
