American Airlines
Oneworld
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United States
Louis Armstrong New Orleans International Airport
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United States
McGhee Tyson Airport
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Scan through all non-stop flights from New Orleans to Knoxville. The full flight schedule below gives an overview of all non-stop flights from MSY to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from New Orleans MSY to Knoxville TYS, which is American Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their MSY TYS flight schedule.
All flights depart at 14:30.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from New Orleans to Knoxville takes 2 hours. The flight distance between New Orleans and Knoxville is 541 miles (or 871 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There are 0 flights per week flying from New Orleans to Knoxville (as of April 2026).
2 hours is the average flight time from New Orleans to Knoxville.
The distance from New Orleans to Knoxville is 541 miles (871 kilometers).
American Airlines is the only airline flying nonstop from New Orleans to Knoxville.
Oneworld is currently the only alliance flying nonstop from New Orleans to Knoxville.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from New Orleans to Knoxville:
The earliest flight departs at 14:30 from New Orleans and arrives at 17:30 at Knoxville.
The latest flight departs at 14:30 from New Orleans and arrives at 17:30 at Knoxville.
541 miles (871 km) · 2h
14:30
17:30
American Airlines
Oneworld
AA 3971
American Airlines
Embraer 175
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W
J
F
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