American Airlines
Oneworld
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United States
McGhee Tyson Airport
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United States
Louis Armstrong New Orleans International Airport
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Scan through all non-stop flights from Knoxville to New Orleans. The full flight schedule below gives an overview of all non-stop flights from TYS to MSY, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
New Orleans is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit New Orleans any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Knoxville TYS to New Orleans MSY, which is American Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their TYS MSY flight schedule.
All flights depart at 12:30.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Knoxville to New Orleans takes 1 hour and 55 minutes. The flight distance between Knoxville and New Orleans is 541 miles (or 871 km).
There is 1 airport in New Orleans: Louis Armstrong New Orleans International Airport (MSY).
There are 0 flights per week flying from Knoxville to New Orleans (as of April 2026).
1 hour and 55 minutes is the average flight time from Knoxville to New Orleans.
The distance from Knoxville to New Orleans is 541 miles (871 kilometers).
American Airlines is the only airline flying nonstop from Knoxville to New Orleans.
Oneworld is currently the only alliance flying nonstop from Knoxville to New Orleans.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Knoxville to New Orleans:
The earliest flight departs at 12:30 from Knoxville and arrives at 13:25 at New Orleans.
The latest flight departs at 12:30 from Knoxville and arrives at 13:25 at New Orleans.
541 miles (871 km) · 1h 55m
12:30
13:25
American Airlines
Oneworld
AA 3971
American Airlines
Embraer 175
Y
W
J
F
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