United Airlines
Star Alliance
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United States
McGhee Tyson Airport
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United States
O'Hare International Airport
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Scan through all non-stop flights from Knoxville to Chicago. The full flight schedule below gives an overview of all non-stop flights from TYS to ORD, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Known for its continental climate, Chicago features hot, humid summers with temperatures above 30°C (86°F) and cold, snowy winters that often drop below 0°C (32°F). This striking seasonal contrast offers travelers a variety of activities, from summer hiking to winter sports, ensuring year-round appeal.
The best time to visit Chicago is from March to November, covering spring, summer, and fall. While summer can be hot, it also sees slightly more rainfall than other seasons.
In total there are 2 airlines operating nonstop flights from Knoxville TYS to Chicago ORD. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their TYS ORD flight schedule.
Flights from TYS to ORD are operated 52 times a week, with an average of 7 flights per day. Departure times vary between 06:30 - 20:48. The earliest flight departs at 06:30, the last flight departs at 20:48. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Knoxville to Chicago takes 2 hours and 3 minutes. The flight distance between Knoxville and Chicago is 474 miles (or 763 km).
There are 2 airports in Chicago: O'Hare International Airport (ORD) and Midway International Airport (MDW).
There are 52 flights per week flying from Knoxville to Chicago (as of April 2026).
2 hours and 3 minutes is the average flight time from Knoxville to Chicago.
The distance from Knoxville to Chicago is 474 miles (763 kilometers).
American Airlines and United Airlines are flying nonstop from Knoxville to Chicago.
Oneworld and Star Alliance are flying nonstop from Knoxville to Chicago.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Knoxville to Chicago:
The earliest flight departs at 06:30 from Knoxville and arrives at 07:29 at Chicago.
The latest flight departs at 20:48 from Knoxville and arrives at 21:57 at Chicago.
474 miles (763 km) · 2h 3m
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-800
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737 MAX 9
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-900
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-800
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-800
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737 MAX 8
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-800
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-800
Y
W
J
F
07:00
07:55
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737-800
Y
W
J
F
07:00
07:56
United Airlines
Star Alliance
UA 1856
United Airlines
Boeing 737 MAX 9
Y
W
J
F
07:40
08:48
American Airlines
Oneworld
AA 5318
American Airlines
Canadair Regional Jet 700
Y
W
J
F
07:50
09:07
American Airlines
Oneworld
AA 5513
American Airlines
Canadair Regional Jet 700
Y
W
J
F
07:50
09:07
American Airlines
Oneworld
AA 5513
American Airlines
Canadair Regional Jet 700
Y
W
J
F
07:50
09:07
American Airlines
Oneworld
AA 5513
American Airlines
Canadair Regional Jet 700
Y
W
J
F
10:49
11:53
United Airlines
Star Alliance
UA 5921
United Airlines
Embraer 175
Y
W
J
F
10:49
11:51
United Airlines
Star Alliance
UA 4444
United Airlines
Bombardier CRJ 550
Y
W
J
F
10:49
11:53
United Airlines
Star Alliance
UA 4745
United Airlines
Bombardier CRJ 550
Y
W
J
F
11:31
12:35
American Airlines
Oneworld
AA 5468
American Airlines
Canadair Regional Jet 700
Y
W
J
F
11:31
12:35
American Airlines
Oneworld
AA 5468
American Airlines
Canadair Regional Jet 700
Y
W
J
F
11:31
12:35
American Airlines
Oneworld
AA 5468
American Airlines
Canadair Regional Jet 700
Y
W
J
F
11:31
12:35
American Airlines
Oneworld
AA 5468
American Airlines
Canadair Regional Jet 700
Y
W
J
F
11:42
12:41
American Airlines
Oneworld
AA 5592
American Airlines
Canadair Regional Jet 700
Y
W
J
F
11:42
12:41
American Airlines
Oneworld
AA 5592
American Airlines
Canadair Regional Jet 700
Y
W
J
F
13:52
14:55
United Airlines
Star Alliance
UA 4501
United Airlines
Bombardier CRJ 550
Y
W
J
F
13:52
14:55
United Airlines
Star Alliance
UA 4501
United Airlines
Bombardier CRJ 550
Y
W
J
F
13:52
14:55
United Airlines
Star Alliance
UA 4501
United Airlines
Bombardier CRJ 550
Y
W
J
F
13:52
14:55
United Airlines
Star Alliance
UA 4501
United Airlines
Bombardier CRJ 550
Y
W
J
F
13:52
14:55
United Airlines
Star Alliance
UA 4501
United Airlines
Bombardier CRJ 550
Y
W
J
F
13:52
14:54
United Airlines
Star Alliance
UA 4691
United Airlines
Bombardier CRJ 550
Y
W
J
F
13:52
14:49
United Airlines
Star Alliance
UA 6020
United Airlines
Bombardier CRJ 550
Y
W
J
F
16:02
17:04
American Airlines
Oneworld
AA 5228
American Airlines
Canadair Regional Jet 700
Y
W
J
F
17:06
18:20
American Airlines
Oneworld
AA 5467
American Airlines
Canadair Regional Jet 700
Y
W
J
F
17:06
18:20
American Airlines
Oneworld
AA 5467
American Airlines
Canadair Regional Jet 700
Y
W
J
F
17:10
18:24
American Airlines
Oneworld
AA 5467
American Airlines
Canadair Regional Jet 700
Y
W
J
F
17:53
18:57
United Airlines
Star Alliance
UA 5904
United Airlines
Embraer 175
Y
W
J
F
17:55
18:50
United Airlines
Star Alliance
UA 777
United Airlines
Airbus A319
Y
W
J
F
20:48
21:57
American Airlines
Oneworld
AA 6461
American Airlines
Canadair Regional Jet 700
Y
W
J
F
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