Flights from Knoxville Flights to Chicago

Direct flights from Knoxville to Chicago

Did you mean flights from Chicago to Knoxville?

Last updated on: 10-06-2026

Knoxville

United States

TYS

McGhee Tyson Airport

Chicago

United States

ORD

O'Hare International Airport

Check Prices

Flight schedule

su

mo

tu

we

th

fr

sa

Distance

474 miles · (763 km)

Flight time

2 hours and 2 minutes

Airlines

American Airlines
United Airlines

Alliances

Oneworld
SkyTeam
Star Alliance

Classes

Economy
Premium Economy
Business Class
First Class

Aircrafts

Airbus A319
Airbus A320-100/200
Bombardier CRJ 550
Canadair Regional Jet 200
Canadair Regional Jet 700
Embraer 170
Embraer 175

Knoxville to Chicago Flight Schedule

Scan through all non-stop flights from Knoxville to Chicago. The full flight schedule below gives an overview of all non-stop flights from TYS to ORD, which includes the daily timetable of every operating airline for the upcoming 12 months.

Note: for airline-specific flight schedules, please scroll further down.

Su

Mo

Tu

We

Th

Fr

Sa

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

Return schedule

Best time to visit Chicago

What is the best time to visit Chicago?

🥵 Hot Continental

Known for its continental climate, Chicago features hot, humid summers with temperatures above 30°C (86°F) and cold, snowy winters that often drop below 0°C (32°F). This striking seasonal contrast offers travelers a variety of activities, from summer hiking to winter sports, ensuring year-round appeal.

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

The best time to visit Chicago is from March to November, covering spring, summer, and fall. While summer can be hot, it also sees slightly more rainfall than other seasons.

Chicago

ORD

Airlines flying from Knoxville to Chicago

Airline-specific flight schedules from Knoxville to Chicago

In total there are 2 airlines operating nonstop flights from Knoxville TYS to Chicago ORD. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.

Click an airline below to view their TYS ORD flight schedule.

American Airlines (AA)

United Airlines (UA)

American Airlines flight schedulefrom Knoxville to Chicago

American Airlines is a member of Oneworld

Su

Mo

Tu

We

Th

Fr

Sa

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

Return schedule

United Airlines flight schedulefrom Knoxville to Chicago

United Airlines is a member of Star Alliance

Su

Mo

Tu

We

Th

Fr

Sa

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

Return schedule

Knoxville to Chicago Flights

Flights from TYS to ORD are operated 51 times a week, with an average of 7 flights per day. Departure times vary between 06:00 - 20:52. The earliest flight departs at 06:00, the last flight departs at 20:52. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.

You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).

The fastest direct flight from Knoxville to Chicago takes 2 hours and 2 minutes. The flight distance between Knoxville and Chicago is 474 miles (or 763 km).

Start planning your trip

Let's find you the best price for this route!

Plan a trip

Frequently asked questions - FAQ

How many airports are there in Chicago?

There are 2 airports in Chicago: O'Hare International Airport (ORD) and Midway International Airport (MDW).

How many flights per week are there from TYS to ORD?

There are 51 flights per week flying from Knoxville to Chicago (as of October 2026).

How long does it take to fly from Knoxville to Chicago?

2 hours and 2 minutes is the average flight time from Knoxville to Chicago.

How far is Chicago from Knoxville?

The distance from Knoxville to Chicago is 474 miles (763 kilometers).

What airlines fly nonstop from TYS airport to ORD airport?

American Airlines and United Airlines are flying nonstop from Knoxville to Chicago.

What alliances have direct flights from Knoxville to Chicago?

Oneworld and Star Alliance are flying nonstop from Knoxville to Chicago.

What classes are available from Knoxville to Chicago?

You can fly non-stop in Economy and Business Class.

What aircraft types fly from Knoxville to Chicago?

Aircraft types that fly from Knoxville to Chicago:

Airbus A319
Airbus A320-100/200
Bombardier CRJ 550
Canadair Regional Jet 200
Canadair Regional Jet 700
Embraer 170
Embraer 175

What is the earliest flight departing from Knoxville to Chicago?

The earliest flight departs at 06:00 from Knoxville and arrives at 06:56 at Chicago.

What is the latest flight available from Knoxville to Chicago?

The latest flight departs at 20:52 from Knoxville and arrives at 21:58 at Chicago.

Popular flights from Knoxville, United States

Knoxville to Charlotte

Knoxville to Atlanta

Knoxville to Chicago

Knoxville to Dallas-Fort Worth

Knoxville to Washington

Knoxville to Philadelphia

Knoxville to New York City

Knoxville to Denver

Knoxville to Houston

Knoxville to Detroit

Knoxville to Washington

Knoxville to Newark

Knoxville to Nashville

Knoxville to Orlando

Show all flights from Knoxville Show all flights to Chicago

Popular routes operated by American Airlines

Chicago to Dallas-Fort Worth

Chicago to Charlotte

Chicago to Washington

Chicago to New York City

Chicago to Philadelphia

Chicago to Miami

Chicago to Boston

Show all American Airlines flights

Popular routes operated by United Airlines

Chicago to Newark

Chicago to Houston

Chicago to Denver

Chicago to New York City

Chicago to San Francisco

Chicago to Washington

Chicago to Los Angeles

Show all United Airlines flights

Popular flights from Knoxville via Chicago

Knoxville to Amsterdam

Knoxville to Athens

Knoxville to Barcelona

Knoxville to Belgrade

Knoxville to Brussels

Knoxville to Cairo

Knoxville to Dublin

Knoxville to Edinburgh

Knoxville to Frankfurt

Knoxville to Helsinki

Knoxville to Istanbul

Knoxville to Copenhagen

Knoxville to Krakow

Knoxville to Lisbon

Knoxville to London Heathrow

Knoxville to Madrid

Knoxville to Milan (Malpensa)

Knoxville to Munich

Knoxville to Naples

Knoxville to Paris

Knoxville to Reykjavik (Keflavik)

Knoxville to Rome (Fiumicino)

Knoxville to Shannon

Knoxville to Warsaw

Knoxville to Vienna

Knoxville to Zürich

Knoxville to Tel Aviv

Knoxville to Amman

Knoxville to Allentown

Knoxville to Albuquerque

Knoxville to Nantucket

Knoxville to Addis Ababa

Knoxville to Albany

Knoxville to Waterloo

Knoxville to Anchorage

Knoxville to Aspen

Knoxville to Appleton

Knoxville to Aruba

Knoxville to Abu Dhabi

Knoxville to Wilkes-Barre

Knoxville to Kalamazoo / Battle Creek

Knoxville to Hartford

Knoxville to Bangor

Knoxville to Billings

Knoxville to Bismarck

Knoxville to León

Knoxville to Bloomington

Knoxville to Bogotá

Knoxville to Boise

Knoxville to Burlington

Knoxville to Burlington

Knoxville to Belize City

Knoxville to Bozeman

Knoxville to Akron

Knoxville to Cape Girardeau

Knoxville to Charlottesville

Knoxville to Cedar Rapids

Knoxville to Clarksburg

Knoxville to Cleveland

Knoxville to Columbus

Knoxville to Champaign-Urbana

Knoxville to Houghton

Knoxville to Colorado Springs

Knoxville to Columbia

Knoxville to Cancún

Knoxville to Willemstad, Curaçao

Knoxville to Wausau

Knoxville to Cozumel

Knoxville to Dayton

Knoxville to Decatur

Knoxville to Duluth

Knoxville to Doha

Knoxville to Des Moines

Knoxville to Dubai

Knoxville to Kearney

Knoxville to Eau Claire

Knoxville to Vail / Eagle

Knoxville to El Paso

Knoxville to Erie

Knoxville to Eugene

Knoxville to Evansville

Knoxville to Fairbanks

Knoxville to Fargo

Knoxville to Fresno

Knoxville to Kalispell

Knoxville to Flint

Knoxville to Fort Dodge

Knoxville to Sioux Falls

Knoxville to Fort Wayne

Knoxville to Grand Cayman

Knoxville to Guadalajara

Knoxville to Spokane

Knoxville to Green Bay

Knoxville to Grand Rapids

Knoxville to São Paulo

Knoxville to Guatemala City

Knoxville to Gunnison

Knoxville to Hayden

Knoxville to Hong Kong

Knoxville to Tokyo

Knoxville to Honolulu

Knoxville to White Plains

Knoxville to Harlingen

Knoxville to Hyannis

Knoxville to Seoul

Knoxville to Wichita

Knoxville to Idaho Falls

Knoxville to Indianapolis

Knoxville to Kirksville

Knoxville to Ironwood

Knoxville to Jackson

Knoxville to New York City

Knoxville to Joplin

Knoxville to Johnstown

Knoxville to Kailua-Kona

Knoxville to Lafayette

Knoxville to Lansing

Knoxville to Los Angeles

Knoxville to Liberia

Knoxville to Little Rock

Knoxville to Lincoln

Knoxville to Lancaster

Knoxville to La Crosse

Knoxville to Montego Bay

Knoxville to Manistee

Knoxville to Saginaw

Knoxville to Kansas City

Knoxville to Mason City

Knoxville to Harrisburg

Knoxville to Mexico City

Knoxville to Morgantown

Knoxville to Manhattan

Knoxville to Manchester

Knoxville to Milwaukee

Knoxville to Muskegon

Knoxville to Moline

Knoxville to Morelia

Knoxville to Manila

Knoxville to Marquette

Knoxville to Monterey

Knoxville to Madison

Knoxville to Missoula

Knoxville to Montrose

Knoxville to Monterrey

Knoxville to Martha's Vineyard

Knoxville to Marion

Knoxville to Nassau

Knoxville to Tokyo

Knoxville to Kahului

Knoxville to Oklahoma City

Knoxville to Omaha

Knoxville to Ontario

Knoxville to Norfolk

Knoxville to Paducah

Knoxville to Puebla

Knoxville to West Palm Beach

Knoxville to Portland

Knoxville to Peoria

Knoxville to Pittsburgh

Knoxville to Providenciales

Knoxville to Pensacola

Knoxville to Palm Springs

Knoxville to Panama City

Knoxville to Punta Cana

Knoxville to Providence

Knoxville to Puerto Vallarta

Knoxville to Provo

Knoxville to Portland

Knoxville to Querétaro

Knoxville to Rapid City

Knoxville to Richmond

Knoxville to Reno

Knoxville to Rochester

Knoxville to Rochester

Knoxville to Fort Myers

Knoxville to Santa Fe

Knoxville to San Diego

Knoxville to San Antonio

Knoxville to Santa Barbara

Knoxville to South Bend

Knoxville to State College

Knoxville to Seattle / Tacoma

Knoxville to San Francisco

Knoxville to Springfield / Branson

Knoxville to Staunton / Waynesboro

Knoxville to Springfield

Knoxville to St. Louis

Knoxville to Saint Thomas

Knoxville to Saint Croix

Knoxville to Hailey / Sun Valley

Knoxville to Sioux City

Knoxville to Sint Maarten

Knoxville to Syracuse

Knoxville to Taipei

Knoxville to Tulsa

Knoxville to Tucson

Knoxville to Traverse City

Knoxville to Quincy

Knoxville to Saint Lucia

Knoxville to Halifax

Knoxville to Ottawa

Knoxville to Quebec City

Knoxville to Toronto

Knoxville to Montreal

Knoxville to Vancouver

Knoxville to Winnipeg

Knoxville to Calgary

Knoxville to Toronto

Knoxville to Ixtapa / Zihuatanejo

Knoxville to San Jose

Knoxville to San José del Cabo

Knoxville to San José

Knoxville to San Juan

Knoxville to Salt Lake City

Knoxville to Sacramento

Knoxville to Santa Ana

Knoxville to Salina

Knoxville to Shreveport

Knoxville to Buffalo

Non-stop flights from TYS to ORD

474 miles (763 km) · 2h 2m

Round trip

1 passenger

Economy

Check Prices

Or compare the best Hotels in Chicago

Return schedule

×

Depart
Arrive
Airline
Flight no
Aircraft
Classes

06:00
06:56
United Airlines

Star Alliance
UA 1553
United Airlines
Airbus A320-100/200
Y
W
J
F

06:00
06:56
United Airlines

Star Alliance
UA 1553
United Airlines
Airbus A320-100/200
Y
W
J
F

06:00
06:56
United Airlines

Star Alliance
UA 1553
United Airlines
Airbus A320-100/200
Y
W
J
F

06:00
06:56
United Airlines

Star Alliance
UA 1553
United Airlines
Airbus A320-100/200
Y
W
J
F

06:00
06:56
United Airlines

Star Alliance
UA 1553
United Airlines
Airbus A320-100/200
Y
W
J
F

06:00
06:56
United Airlines

Star Alliance
UA 1553
United Airlines
Airbus A320-100/200
Y
W
J
F

06:45
07:54
United Airlines

Star Alliance
UA 5524
United Airlines
Embraer 175
Y
W
J
F

06:45
07:54
United Airlines

Star Alliance
UA 5524
United Airlines
Embraer 175
Y
W
J
F

07:30
08:39
American Airlines

Oneworld
AA 4751
American Airlines
Embraer 175
Y
W
J
F

07:30
08:39
American Airlines

Oneworld
AA 4751
American Airlines
Embraer 175
Y
W
J
F

07:30
08:39
American Airlines

Oneworld
AA 4751
American Airlines
Embraer 175
Y
W
J
F

10:42
11:40
United Airlines

Star Alliance
UA 1577
United Airlines
Airbus A319
Y
W
J
F

10:42
11:40
United Airlines

Star Alliance
UA 1577
United Airlines
Airbus A319
Y
W
J
F

10:42
11:40
United Airlines

Star Alliance
UA 1577
United Airlines
Airbus A319
Y
W
J
F

10:43
11:49
United Airlines

Star Alliance
UA 4581
United Airlines
Bombardier CRJ 550
Y
W
J
F

10:43
11:49
United Airlines

Star Alliance
UA 4581
United Airlines
Bombardier CRJ 550
Y
W
J
F

10:45
11:51
United Airlines

Star Alliance
UA 4581
United Airlines
Bombardier CRJ 550
Y
W
J
F

10:51
12:00
United Airlines

Star Alliance
UA 3716
United Airlines
Embraer 175
Y
W
J
F

11:35
12:37
American Airlines

Oneworld
AA 4229
American Airlines
Embraer 175
Y
W
J
F

11:35
12:37
American Airlines

Oneworld
AA 4229
American Airlines
Embraer 175
Y
W
J
F

11:35
12:37
American Airlines

Oneworld
AA 4229
American Airlines
Embraer 175
Y
W
J
F

11:35
12:37
American Airlines

Oneworld
AA 4229
American Airlines
Embraer 175
Y
W
J
F

11:35
12:37
American Airlines

Oneworld
AA 4229
American Airlines
Embraer 175
Y
W
J
F

13:51
14:55
United Airlines

Star Alliance
UA 4460
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:51
14:55
United Airlines

Star Alliance
UA 4460
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:54
14:55
United Airlines

Star Alliance
UA 4460
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:55
14:55
United Airlines

Star Alliance
UA 4548
United Airlines
Bombardier CRJ 550
Y
W
J
F

13:56
14:59
United Airlines

Star Alliance
UA 4460
United Airlines
Bombardier CRJ 550
Y
W
J
F

16:38
17:40
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

16:38
17:40
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

16:38
17:40
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

16:38
17:40
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

16:48
17:50
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

17:07
18:09
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

17:07
18:09
American Airlines

Oneworld
AA 3501
American Airlines
Embraer 175
Y
W
J
F

17:40
18:41
United Airlines

Star Alliance
UA 5478
United Airlines
Bombardier CRJ 550
Y
W
J
F

17:40
18:43
United Airlines

Star Alliance
UA 5478
United Airlines
Embraer 175
Y
W
J
F

17:40
18:43
United Airlines

Star Alliance
UA 3532
United Airlines
Embraer 175
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:08
United Airlines

Star Alliance
UA 5869
United Airlines
Canadair Regional Jet 200
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:08
United Airlines

Star Alliance
UA 5869
United Airlines
Canadair Regional Jet 200
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 4387
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:08
United Airlines

Star Alliance
UA 5869
United Airlines
Canadair Regional Jet 200
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:03
19:05
United Airlines

Star Alliance
UA 5869
United Airlines
Bombardier CRJ 550
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 170
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 175
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 170
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 175
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 170
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 170
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 170
Y
W
J
F

18:55
20:03
American Airlines

Oneworld
AA 3547
American Airlines
Embraer 175
Y
W
J
F