Direct flights from Chicago to Knoxville

Did you mean flights from Knoxville to Chicago?

Last updated on: 04-06-2026

Chicago

United States

ORD

O'Hare International Airport

Knoxville

United States

TYS

McGhee Tyson Airport

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Flight schedule

Distance

474 miles · (763 km)

Flight time

1 hour and 47 minutes

Airlines

American Airlines
United Airlines

Alliances

Oneworld
SkyTeam
Star Alliance

Classes

Economy
Premium Economy
Business Class
First Class

Aircrafts

Airbus A319
Airbus A320-100/200
Boeing 737 MAX 8
Boeing 737 MAX 9
Boeing 737-800
Boeing 737-900
Bombardier CRJ 550
Canadair Regional Jet 700
Embraer 170
Embraer 175

Chicago to Knoxville Flight Schedule

Scan through all non-stop flights from Chicago to Knoxville. The full flight schedule below gives an overview of all non-stop flights from ORD to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.

Note: for airline-specific flight schedules, please scroll further down.

Return schedule

Best time to visit Knoxville

What is the best time to visit Knoxville?

🌺 💦 Humid Subtropical

Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.

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You can visit Knoxville any time of the year, but the best months to explore are from to and from to .

Knoxville

TYS

Airlines flying from Chicago to Knoxville

Airline-specific flight schedules from Chicago to Knoxville

In total there are 2 airlines operating nonstop flights from Chicago ORD to Knoxville TYS. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.

Click an airline below to view their ORD TYS flight schedule.

American Airlines (AA)

United Airlines (UA)

American Airlines flight schedulefrom Chicago to Knoxville

American Airlines is a member of Oneworld

Return schedule

United Airlines flight schedulefrom Chicago to Knoxville

United Airlines is a member of Star Alliance

Return schedule

Chicago to Knoxville Flights

Flights from ORD to TYS are operated 52 times a week, with an average of 7 flights per day. Departure times vary between 06:45 - 21:35. The earliest flight departs at 06:45, the last flight departs at 21:35. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.

You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).

The fastest direct flight from Chicago to Knoxville takes 1 hour and 47 minutes. The flight distance between Chicago and Knoxville is 474 miles (or 763 km).

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