American Airlines
Oneworld
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United States
McGhee Tyson Airport
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United States
Charlotte/Douglas International Airport
Click to show full flight schedule
Scan through all non-stop flights from Knoxville to Charlotte. The full flight schedule below gives an overview of all non-stop flights from TYS to CLT, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Charlotte is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Charlotte any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Knoxville TYS to Charlotte CLT, which is American Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their TYS CLT flight schedule.
Flights from TYS to CLT are operated 55 times a week, with an average of 8 flights per day. Departure times vary between 05:00 - 20:39. The earliest flight departs at 05:00, the last flight departs at 20:39. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Knoxville to Charlotte takes 1 hour and 10 minutes. The flight distance between Knoxville and Charlotte is 176 miles (or 283 km).
There is 1 airport in Charlotte: Charlotte/Douglas International Airport (CLT).
There are 55 flights per week flying from Knoxville to Charlotte (as of April 2026).
1 hour and 10 minutes is the average flight time from Knoxville to Charlotte.
The distance from Knoxville to Charlotte is 176 miles (283 kilometers).
American Airlines is the only airline flying nonstop from Knoxville to Charlotte.
Oneworld is currently the only alliance flying nonstop from Knoxville to Charlotte.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Knoxville to Charlotte:
The earliest flight departs at 05:00 from Knoxville and arrives at 06:20 at Charlotte.
The latest flight departs at 20:39 from Knoxville and arrives at 21:55 at Charlotte.
176 miles (283 km) · 1h 10m
05:00
06:20
American Airlines
Oneworld
AA 5065
American Airlines
Canadair Regional Jet 900
Y
W
J
F
05:00
06:17
American Airlines
Oneworld
AA 5471
American Airlines
Canadair Regional Jet 900
Y
W
J
F
05:00
06:26
American Airlines
Oneworld
AA 5786
American Airlines
Embraer RJ145
Y
W
J
F
05:00
06:17
American Airlines
Oneworld
AA 5471
American Airlines
Canadair Regional Jet 900
Y
W
J
F
06:54
08:20
American Airlines
Oneworld
AA 5182
American Airlines
Canadair Regional Jet 900
Y
W
J
F
07:00
08:26
American Airlines
Oneworld
AA 5182
American Airlines
Canadair Regional Jet 900
Y
W
J
F
07:02
08:28
American Airlines
Oneworld
AA 5182
American Airlines
Canadair Regional Jet 900
Y
W
J
F
08:00
09:30
American Airlines
Oneworld
AA 5208
American Airlines
Canadair Regional Jet 900
Y
W
J
F
08:16
09:46
American Airlines
Oneworld
AA 5208
American Airlines
Canadair Regional Jet 900
Y
W
J
F
08:24
09:51
American Airlines
Oneworld
AA 5208
American Airlines
Canadair Regional Jet 900
Y
W
J
F
08:57
10:29
American Airlines
Oneworld
AA 6132
American Airlines
Embraer RJ145
Y
W
J
F
09:25
10:51
American Airlines
Oneworld
AA 5785
American Airlines
Embraer RJ145
Y
W
J
F
10:22
11:43
American Airlines
Oneworld
AA 6132
American Airlines
Embraer RJ145
Y
W
J
F
11:40
12:59
American Airlines
Oneworld
AA 5941
American Airlines
Embraer RJ145
Y
W
J
F
11:45
13:09
American Airlines
Oneworld
AA 5859
American Airlines
Embraer RJ145
Y
W
J
F
12:11
13:30
American Airlines
Oneworld
AA 5941
American Airlines
Embraer RJ145
Y
W
J
F
13:17
14:43
American Airlines
Oneworld
AA 5161
American Airlines
Canadair Regional Jet 900
Y
W
J
F
13:42
15:06
American Airlines
Oneworld
AA 6085
American Airlines
Embraer RJ145
Y
W
J
F
14:06
15:30
American Airlines
Oneworld
AA 6085
American Airlines
Embraer RJ145
Y
W
J
F
14:49
16:15
American Airlines
Oneworld
AA 6079
American Airlines
Embraer RJ145
Y
W
J
F
14:54
16:20
American Airlines
Oneworld
AA 6079
American Airlines
Embraer RJ145
Y
W
J
F
15:58
17:22
American Airlines
Oneworld
AA 6093
American Airlines
Embraer RJ145
Y
W
J
F
15:58
17:22
American Airlines
Oneworld
AA 6093
American Airlines
Embraer RJ145
Y
W
J
F
16:15
17:43
American Airlines
Oneworld
AA 6093
American Airlines
Embraer RJ145
Y
W
J
F
17:00
18:28
American Airlines
Oneworld
AA 6093
American Airlines
Embraer RJ145
Y
W
J
F
17:47
19:15
American Airlines
Oneworld
AA 6059
American Airlines
Embraer RJ145
Y
W
J
F
17:57
19:22
American Airlines
Oneworld
AA 5878
American Airlines
Embraer RJ145
Y
W
J
F
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