American Airlines
Oneworld
Did you mean flights from Knoxville to Charlotte?
United States
Charlotte/Douglas International Airport
Switch direction
United States
McGhee Tyson Airport
Click to show full flight schedule
Scan through all non-stop flights from Charlotte to Knoxville. The full flight schedule below gives an overview of all non-stop flights from CLT to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .

Currently, there is only one airline operating non-stop flights from Charlotte CLT to Knoxville TYS, which is American Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their CLT TYS flight schedule.
Flights from CLT to TYS are operated 55 times a week, with an average of 8 flights per day. Departure times vary between 07:10 - 22:55. The earliest flight departs at 07:10, the last flight departs at 22:55. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Charlotte to Knoxville takes 1 hour and 4 minutes. The flight distance between Charlotte and Knoxville is 176 miles (or 283 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There are 55 flights per week flying from Charlotte to Knoxville (as of April 2026).
1 hour and 4 minutes is the average flight time from Charlotte to Knoxville.
The distance from Charlotte to Knoxville is 176 miles (283 kilometers).
American Airlines is the only airline flying nonstop from Charlotte to Knoxville.
Oneworld is currently the only alliance flying nonstop from Charlotte to Knoxville.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Charlotte to Knoxville:
The earliest flight departs at 07:10 from Charlotte and arrives at 08:32 at Knoxville.
The latest flight departs at 22:55 from Charlotte and arrives at 00:10 at Knoxville.
176 miles (283 km) · 1h 4m
07:10
08:32
American Airlines
Oneworld
AA 6132
American Airlines
Embraer RJ145
Y
W
J
F
07:19
08:42
American Airlines
Oneworld
AA 6036
American Airlines
Embraer RJ145
Y
W
J
F
08:35
09:57
American Airlines
Oneworld
AA 6132
American Airlines
Embraer RJ145
Y
W
J
F
09:50
11:15
American Airlines
Oneworld
AA 5941
American Airlines
Embraer RJ145
Y
W
J
F
09:53
11:20
American Airlines
Oneworld
AA 5859
American Airlines
Embraer RJ145
Y
W
J
F
10:20
11:45
American Airlines
Oneworld
AA 5941
American Airlines
Embraer RJ145
Y
W
J
F
11:20
12:37
American Airlines
Oneworld
AA 5161
American Airlines
Canadair Regional Jet 900
Y
W
J
F
13:00
14:22
American Airlines
Oneworld
AA 6133
American Airlines
Embraer RJ145
Y
W
J
F
13:02
14:24
American Airlines
Oneworld
AA 6133
American Airlines
Embraer RJ145
Y
W
J
F
13:04
14:24
American Airlines
Oneworld
AA 6079
American Airlines
Embraer RJ145
Y
W
J
F
13:09
14:29
American Airlines
Oneworld
AA 6079
American Airlines
Embraer RJ145
Y
W
J
F
15:45
17:07
American Airlines
Oneworld
AA 5878
American Airlines
Embraer RJ145
Y
W
J
F
15:54
17:16
American Airlines
Oneworld
AA 6041
American Airlines
Embraer RJ145
Y
W
J
F
16:15
17:39
American Airlines
Oneworld
AA 5878
American Airlines
Embraer RJ145
Y
W
J
F
16:46
18:13
American Airlines
Oneworld
AA 5967
American Airlines
Embraer RJ145
Y
W
J
F
16:49
18:13
American Airlines
Oneworld
AA 6089
American Airlines
Embraer RJ145
Y
W
J
F
18:12
19:29
American Airlines
Oneworld
AA 5531
American Airlines
Canadair Regional Jet 900
Y
W
J
F
18:44
20:00
American Airlines
Oneworld
AA 5531
American Airlines
Canadair Regional Jet 900
Y
W
J
F
18:50
20:05
American Airlines
Oneworld
AA 5227
American Airlines
Canadair Regional Jet 900
Y
W
J
F
19:10
20:24
American Airlines
Oneworld
AA 5227
American Airlines
Canadair Regional Jet 900
Y
W
J
F
20:10
21:26
American Airlines
Oneworld
AA 5292
American Airlines
Canadair Regional Jet 900
Y
W
J
F
20:41
21:54
American Airlines
Oneworld
AA 5292
American Airlines
Canadair Regional Jet 900
Y
W
J
F
21:08
22:24
American Airlines
Oneworld
AA 5292
American Airlines
Canadair Regional Jet 900
Y
W
J
F
21:40
23:02
American Airlines
Oneworld
AA 5794
American Airlines
Embraer RJ145
Y
W
J
F
21:40
22:56
American Airlines
Oneworld
AA 5019
American Airlines
Canadair Regional Jet 900
Y
W
J
F
22:35
23:50
American Airlines
Oneworld
AA 5144
American Airlines
Canadair Regional Jet 900
Y
W
J
F
22:40
23:59
American Airlines
Oneworld
AA 5794
American Airlines
Embraer RJ145
Y
W
J
F
22:40
23:55
American Airlines
Oneworld
AA 5019
American Airlines
Canadair Regional Jet 900
Y
W
J
F
22:40
23:59
American Airlines
Oneworld
AA 5794
American Airlines
Embraer RJ145
Y
W
J
F
22:40
23:55
American Airlines
Oneworld
AA 5019
American Airlines
Canadair Regional Jet 900
Y
W
J
F
Click to Check Prices