Southwest Airlines
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United States
San Diego International Airport
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United States
Lambert-Saint Louis International Airport
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Scan through all non-stop flights from San Diego to St. Louis. The full flight schedule below gives an overview of all non-stop flights from SAN to STL, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
St. Louis is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit St. Louis any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from San Diego SAN to St. Louis STL, which is Southwest Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their SAN STL flight schedule.
Flights from SAN to STL are operated 7 times a week, with an average of 1 flight per day. Departure times vary between 06:30 - 14:50. The earliest flight departs at 06:30, the last flight departs at 14:50. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from San Diego to St. Louis takes 3 hours and 30 minutes. The flight distance between San Diego and St. Louis is 1,553 miles (or 2,499 km).
There is 1 airport in St. Louis: Lambert-Saint Louis International Airport (STL).
There are 7 flights per week flying from San Diego to St. Louis (as of April 2026).
3 hours and 30 minutes is the average flight time from San Diego to St. Louis.
The distance from San Diego to St. Louis is 1,553 miles (2,499 kilometers).
Southwest Airlines is the only airline flying nonstop from San Diego to St. Louis.
There are no alliances flying direct from San Diego to St. Louis at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from San Diego to St. Louis:
The earliest flight departs at 06:30 from San Diego and arrives at 12:10 at St. Louis.
The latest flight departs at 14:50 from San Diego and arrives at 20:20 at St. Louis.
1,553 miles (2,499 km) · 3h 30m
07:05
12:35
Southwest Airlines
WN 4451
Southwest Airlines
Boeing 757
Y
W
J
F
07:35
13:05
Southwest Airlines
WN 4451
Southwest Airlines
Boeing 757
Y
W
J
F
13:20
18:50
Southwest Airlines
WN 4534
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
13:20
18:55
Southwest Airlines
WN 1538
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
13:25
18:55
Southwest Airlines
WN 4534
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
13:35
19:10
Southwest Airlines
WN 2281
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
14:50
20:20
Southwest Airlines
WN 2281
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
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