Southwest Airlines
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United States
Lambert-Saint Louis International Airport
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United States
San Diego International Airport
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Scan through all non-stop flights from St. Louis to San Diego. The full flight schedule below gives an overview of all non-stop flights from STL to SAN, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
The Mediterranean regions near San Diego are known for their warm, arid summers, where temperatures often go beyond 30°C (86°F). In some inland spots, the heat can climb even higher, sometimes reaching 40°C (104°F) or more. The winters are pleasantly mild, accompanied by some rainfall. This lovely climate, paired with breathtaking landscapes and bright, sunny days attract visitors from around the globe.
San Diego is a wonderful place to visit all year long, but spring (March-May) and fall (September-November) are the best seasons to visit. The weather is pleasantly warm during these times, especially since the summers can be quite hot in those regions.
Currently, there is only one airline operating non-stop flights from St. Louis STL to San Diego SAN, which is Southwest Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their STL SAN flight schedule.
Flights from STL to SAN are operated 7 times a week, with an average of 1 flight per day. Departure times vary between 07:00 - 21:35. The earliest flight departs at 07:00, the last flight departs at 21:35. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from St. Louis to San Diego takes 4 hours and 5 minutes. The flight distance between St. Louis and San Diego is 1,553 miles (or 2,499 km).
There are 2 airports in San Diego: San Diego International Airport (SAN) and McClellan-Palomar Airport (FAA: CRQ) (CLD).
There are 7 flights per week flying from St. Louis to San Diego (as of April 2026).
4 hours and 5 minutes is the average flight time from St. Louis to San Diego.
The distance from St. Louis to San Diego is 1,553 miles (2,499 kilometers).
Southwest Airlines is the only airline flying nonstop from St. Louis to San Diego.
There are no alliances flying direct from St. Louis to San Diego at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from St. Louis to San Diego:
The earliest flight departs at 07:00 from St. Louis and arrives at 09:00 at San Diego.
The latest flight departs at 21:35 from St. Louis and arrives at 23:15 at San Diego.
1,553 miles (2,499 km) · 4h 5m
07:00
09:00
Southwest Airlines
WN 4515
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
08:25
10:30
Southwest Airlines
WN 2548
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
08:25
10:25
Southwest Airlines
WN 4515
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
08:25
10:25
Southwest Airlines
WN 4515
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
08:30
10:30
Southwest Airlines
WN 4515
Southwest Airlines
Boeing 737-800 (winglets)
Y
W
J
F
08:35
10:40
Southwest Airlines
WN 2548
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
14:35
16:30
Southwest Airlines
WN 2639
Southwest Airlines
Boeing 737 MAX 8
Y
W
J
F
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