Sky High
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Dominican Republic
Las Américas International Airport
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Cuba
Antonio Maceo International Airport
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Scan through all non-stop flights from Santo Domingo to Santiago de Cuba. The full flight schedule below gives an overview of all non-stop flights from SDQ to SCU, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Santiago de Cuba is a tropical destination known for its warm climate, with temperatures between 25°C and 30°C (77°F to 86°F) throughout the year. The area is characterized by high humidity and frequent rainfall.
Being located north of the equator, Santiago de Cuba experiences its dry season from November to April, making this the perfect time to visit. In this period, you can expect mostly dry conditions, while the wet season will see days of rain. Humidity and temperatures are consistently high all year long.
Currently, there is only one airline operating non-stop flights from Santo Domingo SDQ to Santiago de Cuba SCU, which is Sky High. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their SDQ SCU flight schedule.
Flights from SDQ to SCU are operated twice a week. Departure times vary between 02:50 - 09:30. The earliest flight departs at 02:50, the last flight departs at 09:30. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Santo Domingo to Santiago de Cuba takes 20 minutes. The flight distance between Santo Domingo and Santiago de Cuba is 415 miles (or 668 km).
There is 1 airport in Santiago de Cuba: Antonio Maceo International Airport (SCU).
There are 2 flights per week flying from Santo Domingo to Santiago de Cuba (as of May 2026).
20 minutes is the average flight time from Santo Domingo to Santiago de Cuba.
The distance from Santo Domingo to Santiago de Cuba is 415 miles (668 kilometers).
Sky High is the only airline flying nonstop from Santo Domingo to Santiago de Cuba.
There are no alliances flying direct from Santo Domingo to Santiago de Cuba at the moment.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Santo Domingo to Santiago de Cuba:
The earliest flight departs at 02:50 from Santo Domingo and arrives at 05:00 at Santiago de Cuba.
The latest flight departs at 09:30 from Santo Domingo and arrives at 09:40 at Santiago de Cuba.
415 miles (668 km) · 20m
02:50
05:00
Sky High
DO 822
Sky High
Embraer 190
Y
W
J
F
06:30
06:50
Sky High
DO 820
Sky High
Embraer 190
Y
W
J
F
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