Southwest Airlines
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United States
Tampa International Airport
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United States
McGhee Tyson Airport
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Scan through all non-stop flights from Tampa to Knoxville. The full flight schedule below gives an overview of all non-stop flights from TPA to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Tampa TPA to Knoxville TYS, which is Southwest Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their TPA TYS flight schedule.
Flights from TPA to TYS are operated once a week. All flights depart at 12:20.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Tampa to Knoxville takes 1 hour and 45 minutes. The flight distance between Tampa and Knoxville is 547 miles (or 880 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There is 1 flight per week flying from Tampa to Knoxville (as of April 2026).
1 hour and 45 minutes is the average flight time from Tampa to Knoxville.
The distance from Tampa to Knoxville is 547 miles (880 kilometers).
Southwest Airlines is the only airline flying nonstop from Tampa to Knoxville.
There are no alliances flying direct from Tampa to Knoxville at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Tampa to Knoxville:
The earliest flight departs at 12:20 from Tampa and arrives at 14:05 at Knoxville.
The latest flight departs at 12:20 from Tampa and arrives at 14:05 at Knoxville.
547 miles (880 km) · 1h 45m
12:20
14:05
Southwest Airlines
WN 41
Southwest Airlines
Boeing 757
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