Allegiant
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United States
Midway International Airport
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United States
McGhee Tyson Airport
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Scan through all non-stop flights from Chicago to Knoxville. The full flight schedule below gives an overview of all non-stop flights from MDW to TYS, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Knoxville is a humid subtropical or warm-temperate destination, featuring hot, humid summers with temperatures typically around 30°C (86°F) and mild to cool winters. The region is known for consistent rainfall throughout the year, peaking in summer. The area is known for its vibrant urban energy, diverse landscapes, and numerous outdoor activities.
You can visit Knoxville any time of the year, but the best months to explore are from to and from to .
Currently, there is only one airline operating non-stop flights from Chicago MDW to Knoxville TYS, which is Allegiant. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their MDW TYS flight schedule.
Flights from MDW to TYS are operated once a week. Departure times vary between 12:36 - 20:09. The earliest flight departs at 12:36, the last flight departs at 20:09. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Chicago to Knoxville takes 1 hour and 28 minutes. The flight distance between Chicago and Knoxville is 459 miles (or 739 km).
There is 1 airport in Knoxville: McGhee Tyson Airport (TYS).
There is 1 flight per week flying from Chicago to Knoxville (as of April 2026).
1 hour and 28 minutes is the average flight time from Chicago to Knoxville.
The distance from Chicago to Knoxville is 459 miles (739 kilometers).
Allegiant is the only airline flying nonstop from Chicago to Knoxville.
There are no alliances flying direct from Chicago to Knoxville at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Chicago to Knoxville:
The earliest flight departs at 12:36 from Chicago and arrives at 15:01 at Knoxville.
The latest flight departs at 20:09 from Chicago and arrives at 22:39 at Knoxville.
459 miles (739 km) · 1h 28m
14:47
17:13
Allegiant
G4 3061
Allegiant
Airbus A320-100/200
Y
W
J
F
14:47
17:13
Allegiant
G4 1420
Allegiant
Airbus A320-100/200
Y
W
J
F
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