Allegiant
Did you mean flights from Chicago to Knoxville?
United States
McGhee Tyson Airport
Switch direction
United States
Midway International Airport
Click to show full flight schedule
Scan through all non-stop flights from Knoxville to Chicago. The full flight schedule below gives an overview of all non-stop flights from TYS to MDW, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Known for its continental climate, Chicago features hot, humid summers with temperatures above 30°C (86°F) and cold, snowy winters that often drop below 0°C (32°F). This striking seasonal contrast offers travelers a variety of activities, from summer hiking to winter sports, ensuring year-round appeal.
The best time to visit Chicago is from March to November, covering spring, summer, and fall. While summer can be hot, it also sees slightly more rainfall than other seasons.
Currently, there is only one airline operating non-stop flights from Knoxville TYS to Chicago MDW, which is Allegiant. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their TYS MDW flight schedule.
Flights from TYS to MDW are operated once a week. Departure times vary between 11:14 - 18:42. The earliest flight departs at 11:14, the last flight departs at 18:42. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Knoxville to Chicago takes 1 hour and 34 minutes. The flight distance between Knoxville and Chicago is 459 miles (or 739 km).
There are 2 airports in Chicago: Midway International Airport (MDW) and O'Hare International Airport (ORD).
There is 1 flight per week flying from Knoxville to Chicago (as of April 2026).
1 hour and 34 minutes is the average flight time from Knoxville to Chicago.
The distance from Knoxville to Chicago is 459 miles (739 kilometers).
Allegiant is the only airline flying nonstop from Knoxville to Chicago.
There are no alliances flying direct from Knoxville to Chicago at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Knoxville to Chicago:
The earliest flight departs at 11:14 from Knoxville and arrives at 11:46 at Chicago.
The latest flight departs at 18:42 from Knoxville and arrives at 19:19 at Chicago.
459 miles (739 km) · 1h 34m
13:22
13:57
Allegiant
G4 3049
Allegiant
Airbus A320-100/200
Y
W
J
F
13:22
13:57
Allegiant
G4 1440
Allegiant
Airbus A320-100/200
Y
W
J
F
Click to Check Prices
