Avianca
Star Alliance
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Colombia
José María Córdova International Airport
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Ecuador
José Joaquín de Olmedo International Airport
Click to show full flight schedule
Scan through all non-stop flights from Medellín to Guayaquil. The full flight schedule below gives an overview of all non-stop flights from MDE to GYE, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Guayaquil is a tropical destination known for its warm climate, with temperatures between 25°C and 30°C (77°F to 86°F) throughout the year. The area is characterized by high humidity and frequent rainfall.
Since Guayaquil is situated south of the equator, the dry season runs from May to October. This makes it the ideal time to visit. During these months, you can expect mostly dry weather, while the wet season can bring days of rain. Temperatures remain high year-round, along with high humidity levels.
Currently, there is only one airline operating non-stop flights from Medellín MDE to Guayaquil GYE, which is Avianca. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their MDE GYE flight schedule.
Flights from MDE to GYE are operated 3 times a week, with an average of 1 flight per day. Departure times vary between 16:10 - 18:25. The earliest flight departs at 16:10, the last flight departs at 18:25. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Medellín to Guayaquil takes 2 hours. The flight distance between Medellín and Guayaquil is 651 miles (or 1,048 km).
There is 1 airport in Guayaquil: José Joaquín de Olmedo International Airport (GYE).
There are 3 flights per week flying from Medellín to Guayaquil (as of April 2026).
2 hours is the average flight time from Medellín to Guayaquil.
The distance from Medellín to Guayaquil is 651 miles (1,048 kilometers).
Avianca is the only airline flying nonstop from Medellín to Guayaquil.
Star Alliance is currently the only alliance flying nonstop from Medellín to Guayaquil.
You can fly non-stop in Economy only.
Aircraft types that fly from Medellín to Guayaquil:
The earliest flight departs at 16:10 from Medellín and arrives at 18:10 at Guayaquil.
The latest flight departs at 18:25 from Medellín and arrives at 20:25 at Guayaquil.
651 miles (1,048 km) · 2h
16:50
18:50
Avianca
Star Alliance
AV 8399
Avianca
Airbus A320-100/200
Y
W
J
F
16:50
18:50
Avianca
Star Alliance
AV 8399
Avianca
Airbus A320neo
Y
W
J
F
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