TUI Fly
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Italy
Palermo Airport (Falcone-Borsellino Airport)
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Belgium
Brussels Airport (Zaventem Airport)
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Scan through all non-stop flights from Palermo to Brussels. The full flight schedule below gives an overview of all non-stop flights from PMO to BRU, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Brussels is an oceanic/maritime destination, known for its mild summer temperatures, which are usually between 15°C and 25°C (59°F to 77°F). The winters here are refreshingly cool, without the harshness of freezing temperatures. Visitors can enjoy the green surroundings and plenty of outdoor adventures in the nearby areas, making it an excellent choice for those who enjoy temperate weather.
The best time to visit Brussels is during the summer months, spanning from May to August. During this period, visitors can expect pleasant to warm temperatures, while rainfall tends to occur more frequently in the autumn and winter months, from September to February.

Currently, there is only one airline operating non-stop flights from Palermo PMO to Brussels BRU, which is TUI Fly. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their PMO BRU flight schedule.
Flights from PMO to BRU are operated twice a week. Departure times vary between 11:05 - 20:00. The earliest flight departs at 11:05, the last flight departs at 20:00. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Palermo to Brussels takes 2 hours and 55 minutes. The flight distance between Palermo and Brussels is 973 miles (or 1,566 km).
There are 2 airports in Brussels: Brussels Airport (Zaventem Airport) (BRU) and Brussels South Charleroi Airport (CRL).
There are 2 flights per week flying from Palermo to Brussels (as of April 2026).
2 hours and 55 minutes is the average flight time from Palermo to Brussels.
The distance from Palermo to Brussels is 973 miles (1,566 kilometers).
TUI Fly is the only airline flying nonstop from Palermo to Brussels.
There are no alliances flying direct from Palermo to Brussels at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Palermo to Brussels:
The earliest flight departs at 11:05 from Palermo and arrives at 14:00 at Brussels.
The latest flight departs at 20:00 from Palermo and arrives at 22:55 at Brussels.
973 miles (1,566 km) · 2h 55m
11:05
14:00
TUI Fly
TB 3581
TUI Fly
Boeing 737 MAX 8
Y
W
J
F
18:30
21:25
TUI Fly
TB 3581
TUI Fly
Boeing 737-800 (winglets)
Y
W
J
F
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