Copa Airlines
Star Alliance
Did you mean flights from Santa Cruz de la Sierra to Panama City?
Panama
Tocumen International Airport
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Bolivia
Viru Viru International Airport
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Scan through all non-stop flights from Panama City to Santa Cruz de la Sierra. The full flight schedule below gives an overview of all non-stop flights from PTY to VVI, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Santa Cruz de la Sierra is a tropical destination known for its warm climate, with temperatures between 25°C and 30°C (77°F to 86°F) throughout the year. The area is characterized by high humidity and frequent rainfall.
Since Santa Cruz de la Sierra is situated south of the equator, the dry season runs from May to October. This makes it the ideal time to visit. During these months, you can expect mostly dry weather, while the wet season can bring days of rain. Temperatures remain high year-round, along with high humidity levels.
Currently, there is only one airline operating non-stop flights from Panama City PTY to Santa Cruz de la Sierra VVI, which is Copa Airlines. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their PTY VVI flight schedule.
Flights from PTY to VVI are operated 11 times a week, with an average of 2 flights per day. Departure times vary between 16:40 - 21:43. The earliest flight departs at 16:40, the last flight departs at 21:43. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
You can fly in Economy and Business Class. Premium Economy and First Class are not available on this route (at least not as a non-stop flight).
The fastest direct flight from Panama City to Santa Cruz de la Sierra takes 5 hours and 2 minutes. The flight distance between Panama City and Santa Cruz de la Sierra is 2,152 miles (or 3,463 km).
There is 1 airport in Santa Cruz de la Sierra: Viru Viru International Airport (VVI).
There are 11 flights per week flying from Panama City to Santa Cruz de la Sierra (as of April 2026).
5 hours and 2 minutes is the average flight time from Panama City to Santa Cruz de la Sierra.
The distance from Panama City to Santa Cruz de la Sierra is 2,152 miles (3,463 kilometers).
Copa Airlines is the only airline flying nonstop from Panama City to Santa Cruz de la Sierra.
Star Alliance is currently the only alliance flying nonstop from Panama City to Santa Cruz de la Sierra.
You can fly non-stop in Economy and Business Class.
Aircraft types that fly from Panama City to Santa Cruz de la Sierra:
The earliest flight departs at 16:40 from Panama City and arrives at 22:42 at Santa Cruz de la Sierra.
The latest flight departs at 21:43 from Panama City and arrives at 03:40 at Santa Cruz de la Sierra.
2,152 miles (3,463 km) · 5h 2m
16:40
22:42
Copa Airlines
Star Alliance
CM 127
Copa Airlines
Boeing 737-800
Y
W
J
F
21:43
03:40
Copa Airlines
Star Alliance
CM 221
Copa Airlines
Boeing 737-800
Y
W
J
F
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