Allegiant
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United States
McGhee Tyson Airport
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United States
Key West International Airport
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Scan through all non-stop flights from Knoxville to Key West. The full flight schedule below gives an overview of all non-stop flights from TYS to EYW, which includes the daily timetable of every operating airline for the upcoming 12 months.
Note: for airline-specific flight schedules, please scroll further down.
Key West is a tropical destination known for its warm climate, with temperatures between 25°C and 30°C (77°F to 86°F) throughout the year. The area is characterized by high humidity and frequent rainfall.
Being located north of the equator, Key West experiences its dry season from November to April, making this the perfect time to visit. In this period, you can expect mostly dry conditions, while the wet season will see days of rain. Humidity and temperatures are consistently high all year long.
Currently, there is only one airline operating non-stop flights from Knoxville TYS to Key West EYW, which is Allegiant. This section gives an overview of the flight schedules and timetables of every airline with direct flights for this route.
Click an airline below to view their TYS EYW flight schedule.
Flights from TYS to EYW are operated twice a week. Departure times vary between 06:00 - 09:00. The earliest flight departs at 06:00, the last flight departs at 09:00. However, this depends on the date you are flying so please check with the full flight schedule above to see which departure times are available on your preferred date(s) of travel.
On this non-stop route, you can fly in Economy only.
The fastest direct flight from Knoxville to Key West takes 2 hours and 11 minutes. The flight distance between Knoxville and Key West is 788 miles (or 1,268 km).
There is 1 airport in Key West: Key West International Airport (EYW).
There are 2 flights per week flying from Knoxville to Key West (as of April 2026).
2 hours and 11 minutes is the average flight time from Knoxville to Key West.
The distance from Knoxville to Key West is 788 miles (1,268 kilometers).
Allegiant is the only airline flying nonstop from Knoxville to Key West.
There are no alliances flying direct from Knoxville to Key West at the moment.
You can fly non-stop in Economy only.
Aircraft types that fly from Knoxville to Key West:
The earliest flight departs at 06:00 from Knoxville and arrives at 08:11 at Key West.
The latest flight departs at 09:00 from Knoxville and arrives at 11:04 at Key West.
788 miles (1,268 km) · 2h 11m
08:00
10:11
Allegiant
G4 1396
Allegiant
Airbus A320-100/200
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